Korelasi antara Faktor Reumatoid dan Vascular Cell Adhesion Molecule-1 pada Pasien Artritis Reumatoid Tanpa Sindroma Metabolik

Reza Yogaswara, Rudy Hidayat, Muhadi Muhadi, Ikhwan Rinaldi

Abstract

Pendahuluan. Komplikasi kardiovaskular yang disebabkan oleh disfungsi endotel menjadi salah satu penyebab mortalitas yang cukup tinggi pada pasien Artritis Reumatoid (AR). Faktor Reumatoid (RF) merupakan autoantibodi yang sering dijumpai pada AR dan diduga dapat meningkatkan respon inflamasi dan disfungsi endotel. Sindroma metabolik dapat pula meningkatkan disfungsi endotel. Belum ada studi yang menilai korelasi RF dan disfungsi endotel pada pasien AR tanpa sindroma metabolik. Penelitian ini bertujuan untuk mengetahui korelasi antara kadar RF dengan kadar VCAM-1 pada pasien AR tanpa sindroma metabolik.

Metode. Penelitian desain potong lintang terhadap pasien AR dewasa yang berobat di Poliklinik Reumatologi RSUPN Cipto Mangunkusumo tanpa sindroma metabolik. Pengumpulan data dilakukan sejak Februari hingga Maret 2018 dari data penelitian sebelumnya yang diambil periode Februari 2016 hingga September 2017. Kadar RF dan VCAM-1 dinilai melalui pemeriksaan serum darah dengan metode ELISA. Korelasi antarkedua variabel dibuat dengan analisis korelasi Spearman menggunakan SPSS versi 20.0.

Hasil. Sebanyak 46 subjek diikutsertakan dalam penelitian ini. Sebagian besar (95,7%) subjek adalah perempuan dengan rerata usia 44,43 tahun, median lama sakit 36 bulan, dan sebagian besar memiliki derajat aktivitas sedang (52,2%). sebagian besar pasien memiliki RF positif (63%). Korelasi antara kadar RF dengan kadar VCAM-1 memiliki kekuatan korelasi yang lemah tetapi tidak bermakna secara statistik (r=0,264; p=0,076). Subjek dengan RF positif memiliki kadar VCAM-1 yang lebih tinggi (626,89 vs. 540,96 ng/mL).

Simpulan. Belum didapatkan korelasi antara RF dengan VCAM-1 pada pasien Artritis Reumatoid tanpa sindroma metabolik.

Kata Kunci: Artritis reumatoid, Faktor reumatoid, Sindroma metabolik, Vascular Cell Adhesion Molecule-1

Correlation between Rheumatoid Factor and Vascular Cell Adhesion Molecule-1 Levels in Rheumatoid Arthritis Patients without Metabolic Syndrome

Introduction. Cardiovascular complications caused by endothelial dysfunction become one of the highest causes of mortality in patients with Rheumatoid Arthritis (RA). Rheumatoid Factor (RF) is an autoantibody that is commonly found in RA and is thought increasing the inflammatory response and endothelial dysfunction. Metabolic syndrome may also increase endothelial dysfunction. There have been no study assessing correlation between RF and endothelial dysfunction in RA patients without metabolic syndrome. Aim of this study was to determine the correlation between RF levels with VCAM-1 levels in RA patients without metabolic syndrome.

Methods. Cross sectional design study of adult RA patients treated in Rheumatology Polyclinic of Cipto Mangunkusumo General Hospital without metabolic syndrome. Data collection was conducted from February to March 2018 from the previous research data taken from February 2016 to September 2017. The levels of RF and VCAM-1 were assessed through blood serum testing using the ELISA method. Correlation between the two variables was made using Spearman correlation analysis with SPSS 20.0

Results. A total of 46 subjects were included in the study. Most (95.7%) subjects were women with an average age of 44.43 years, median duration of 36 months, and most had moderate activity (52.2%). Most patients had a positive RF (63%). The correlation between RF levels and VCAM-1 levels had a weak correlation strength but was not statistically significant (r= 0.264; p= 0.076). Subjects with RF positive had higher levels of VCAM-1 (626.89 vs. 540.96 ng / mL).

Conclusion. There is no correlation yet between RF and VCAM-1 in RA patient s without metabolic syndrome.


Keywords

Metabolic Syndrome, Rheumatoid Arthritis, Rheumatoid Factor, Vascular Cell Adhesion Molecule-1

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